Liver & Gallbladder Support

What is Liver & Gallbladder Support?
Liver & Gallbladder Support is designed to support bile flow for the normal processing and elimination of toxins through a specialized combination of nutrients and herbs. By supporting liver and gallbladder function, Liver & Gallbladder Support promotes the elimination of fatty substances from the liver and the breakdown and absorption of fats and fat-soluble vitamins.*

What are the ingredients in Rootcology Liver & Gallbladder Support?
This proprietary blend contains vitamins A, B6 and B12, L-methionine, milk thistle, taurine, inositol, ox bile, artichoke, and beet powder, to support the liver’s ability to process fat, help maintain normal production of bile, and support a healthy bile flow.*

What are the benefits of Liver & Gallbladder Support?
Liver & Gallbladder Support may be beneficial for anyone in need of liver or gallbladder support, those who need support for fat digestion, anyone needing detoxification support, and anyone experiencing occasional digestive distress such as bloating or gas.*

What is the recommended dose?
The recommended dose is three capsules per day.

When should I take Liver and Gallbladder Support?
One capsule with breakfast, one with lunch, and one with dinner, is recommended.

How long should I take Liver & Gallbladder Support for?
Liver & Gallbladder Support can be taken for 2 weeks during a liver support protocol, or long-term if needed.

Can it be taken with thyroid medications?
Liver & Gallbladder Support is safe to take with thyroid medications, but be sure to space them out by at least one hour. Testing your thyroid hormone levels every 30-90 days to see if a medication adjustment is needed, is recommended.

I no longer have a gallbladder. Can I take this supplement?
Yes, Liver & Gallbladder Support can be taken by those without a gallbladder.

Can Liver & Gallbladder Support be used by those who have a history of gallstones?
Liver & Gallbladder Support is generally safe to use for those who are prone to gallstones.

Why can’t I take Liver & Gallbladder Support if I have Addison’s, an electrolyte imbalance, or am taking steroids or diuretic medications?
Some ingredients in the Liver & Gallbladder Support (including milk thistle and artichoke) may upregulate liver pathways that eliminate medications (specifically, the P450 enzyme). This can be an issue with steroids and diuretics, which can result in electrolyte imbalances due to excess excretion, or keeping the drug in the body too long.

Those with severe adrenal issues, like Addison's, may also be at greater risk for electrolyte imbalance, which may be exacerbated by detoxing.

Not to be used by those with Addison's disease or a history of electrolyte imbalance. Do not use if you are allergic or sensitive to any of the ingredients in this supplement.

This product contains milk thistle. Milk thistle has been known to cause gastrointestinal issues, itchiness, headaches, and can cause an allergic reaction in people who are allergic to other plants in the Asteraceae family, such as ragweed, daisies, marigolds, and chrysanthemums. 

If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. There is also concern that milk thistle might have estrogenic effects. If you have breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids, consider avoiding milk thistle.

Consult with a doctor before use if pregnant or breastfeeding.

DO NOT TAKE if taking the following medications: blood thinners, diuretics, dupilumab (Dupixent), steroid medications, or retinoids including acitretin (Soriatane), bexarotene (Targretin), etretinate (Tegison), isotretinoin (Accutane), tretinoin (Retin-A, Renova), and tazarotene (Avage), antidiabetic drugs, Cytochrome P450 1A2, 2B6, 2C19, or 2D6 substrates, diclofenac, glucuronidated drugs, HMG-CoA reductase inhibitors, immunosuppressants, lithium, monoamine oxidase inhibitors, monoclonal antibodies (MABs), morphine, niacin, p-glycoprotein substrates, quinolone antibiotics, raloxifene, sirolimus, or tamoxifen.

Furthermore, Liver & Gallbladder Support should not be taken by those using certain medications that have the potential to be toxic to the liver, including acetaminophen (Tylenol), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), or tetracycline-based antibiotics, including demeclocycline (Declomycin), minocycline (Minocin), and tetracycline.

1. Murakami S, Fujita M, Nakamura M, Sakono M, Nishizono S, Sato M, Imaizumi K,Mori M, Fukuda N. Taurine ameliorates cholesterol metabolism by stimulating bile acid production in high-cholesterol-fed rats. Clin Exp Pharmacol Physiol. 2016 Mar;43(3):372-8.
2. Akande MG, Shittu M, Uchendu C, Yaqub LS. Taurine ameliorated thyroid function in rats co-administered with chlorpyrifos and lead. Vet Res Commun. 2016 Dec;40(3-4):123-129. Epub 2016 Aug 25.
3. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Drug Metab Dispos. 2014;42(10):1611-6.
4. Alzawqari M, Moghaddam HN, Kermanshahi H, et al. The effect of desiccated ox bile supplementation on performance, fat digestibility, gut morphology and blood chemistry of broiler chickens fed tallow diets, Journal of Applied Animal Research. 2011;39:2, 169-174.
5. Methionine. National Center for Biotechnology Information. PubChem Compound Database; CID=6137. https://pubchem.ncbi.nlm.nih.gov/compound/Methionine. Accessed March 3, 2019.
6. Methionine. WebMD. https://www.webmd.com/vitamins/ai/ingredientmono-42/methionine. Accessed March 3, 2019.
7. Zhao SS, Li NR, Zhao WL, et al. D-chiro-inositol effectively attenuates cholestasis in bile duct ligated rats by improving bile acid secretion and attenuating oxidative stress. Acta Pharmacol Sin. 2018 Feb;39(2):213-221.
8. del Pozo R, Muñoz M, Dumas A, et al. Effects of vitamin C administration on cholesterol gallstone formation]. Rev Med Chil. 2014 Jan;142(1):20-6.
9. Krajka-Kuźniak V, Szaefer H, Ignatowicz E, et al. Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats. Food Chem Toxicol. 2012 Jun;50(6):2027-33.
10. Natural Medicines Therapeutic Research Collaboration. https://naturalmedicines.therapeuticresearch.com/. Accessed August 5, 2020.
11. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Drug Metab Dispos. 2014;42(10):1611-6.
12. Karimi G, Vahabzadeh M, Lari P, Rashedinia M, Moshiri M. “Silymarin”, a promising pharmacological agent for treatment of diseases. Iran J Basic Med Sci. 2011;14(4):308-17.
13. Kazazis CE, Evangelopoulos AA, Kollas A, et al. The therapeutic potential of milk thistle in diabetes. Rev Diabet Stud. 2014;11(2):167-74.
14. Milk Thistle. Mayo Clinic website. https://www.mayoclinic.org/drugs-supplements-milk-thistle/art-20362885. Published October 14, 2017. Accessed July 3, 2020.