What is Pure N-Acetyl Cysteine?
Pure N-Acetyl Cysteine is an amino acid that is a precursor to glutathione, the body’s most powerful antioxidant, and helps promote optimal detoxification. NAC is heavily researched for its role in optimizing lung health and is also used for rapid recovery after workouts. It is also beneficial for protection against normal exposure to heavy metals.*
What are the benefits of Pure N-Acetyl Cysteine?
N-Acetyl Cysteine helps to maintain proper levels of the antioxidant glutathione, support the natural detoxification process and muscle recovery after exertion, protect against normal exposure to heavy metals, and support healthy lung function.*
What is the recommended dose?
One to two capsules per day is recommended.
When should I take it?
This supplement should be taken at meals, with food.
Can it be taken with thyroid medications?
Pure N-Acetyl Cysteine should be taken at least 30 to 60 minutes away from thyroid medications. Testing your thyroid hormone levels every 30-90 days to see if a medication adjustment is needed, is recommended.
How long can I take Pure N-Acetyl Cysteine for?
Pure N-Acetyl Cysteine can be taken for 3 months to 2 years.
Should I avoid Pure N-Acetyl Cysteine if I am allergic to Sulfa drugs?
Sulfa (a medication) and sulfur/sulphur (a compound) are different. Since N-Acetyl Cysteine is a sulfur/sulphur-based supplement, it should be avoided by those who are sensitive to sulfur/sulphur. However, N-Acetyl Cysteine does not contain Sulfa.
Are there any side effects that I should be aware of when taking Pure N-Acetyl Cysteine?
N-Acetyl Cysteine may cause diarrhea. Taking it with food may lessen the likelihood of this reaction.
Do not use if you have a sulfur sensitivity, are prone to fainting, or if you are allergic or sensitive to any of the ingredients in this supplement. Use with caution if you have a CBS gene variation.
Discontinue use at least two weeks prior to undergoing surgery.
Consult with a doctor before use if pregnant or breastfeeding, or if you have asthma.
Avoid if taking the following medications: ACE inhibitors, activated charcoal, anticoagulant/antiplatelet drugs, antihypertensive drugs, blood thinners, chloroquine, or nitroglycerin.
- Nimni ME, Han B, Cordoba F. Are we getting enough sulfur in our diet?. Nutrition & Metabolism (London). 2007;4:24.
- Mokhtari V, Afsharian P, Shahhoseini M, Kalantar SM, Moini, A. A Review on Various Uses of N-Acetyl Cysteine. Cell Journalism. 2017;19(1):11–17.
- Fowdar K, Chen H, He Z, Zhang J, Zhong X, Zhang J, et al. The effect of N-acetylcysteine on exacerbations of chronic obstructive pulmonary disease: A meta-analysis and systematic review. Heart & Lung: The Journal of Medical Care. 2017;46(2):120-128. doi: 10.1016/j.hrtlng.2016.12.004.
- Chaumais MC, Ranchoux B, Montani D, Dorfmüller P, Tu L, Lecerf F, et al. N-acetylcysteine improves established monocrotaline-induced pulmonary hypertension in rats. Respiratory Research. 2014;15:65. doi: 10.1186/1465-9921-15-65.
- Sacco R, Eggenhoffner R, Giacomelli L. Glutathione in the treatment of liver diseases: insights from clinical practice. Minerva Gastroenterologica e Dietologica. 2016;62(4):316-324.
- Khoshbaten M, Aliasgarzadeh A, Masnadi K, Tarzamani MK, Farhang S, Babaei H, et al. N-acetylcysteine improves liver function in patients with non-alcoholic Fatty liver disease. Hepatitis Monthly. 2010;10(1):12-6.
- McLeay Y, Stannards, Houltham S, Starck C. Dietary thiols in exercise: oxidative stress defence, exercise performance, and adaptation. Journal of the International Society of Sports Nutrition. 2017;14:12.
- Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. American Journal of Physiology. 2000 Dec;279(6):L1005-28.
- Auten RL, Davis JM. Oxygen toxicity and reactive oxygen species: the devil is in the details. Pediatric Research. 2009;66(2):121-7. doi:10.1203/PDR.0b013e3181a9eafb.
- Bouayed J, Rammal H, Soulimani R. Oxidative stress and anxiety: Relationship and cellular pathways. Oxidative Medicine and Cellular Longevity. 2009;2(2):63-67.
- Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. The Journal of Nutrition. 2004;134(3):489-92.
- Dringen R. Metabolism and functions of glutathione in brain. Progress in Neurobiology. 2000;62(6):649-71.
- Ruggeri RM, Vicchio TM, Cristani M, Certo R, Caccamo D, Alibrandi A, et al. Oxidative Stress and Advanced Glycation End Products in Hashimoto’s Thyroiditis. Thyroid. 2016 Apr;26(4):504-11. doi: 10.1089/thy.2015.0592.
- Steele ML, Fuller S, Maczurek AE, Kersaitis C, Ooi L, Münch G. Chronic inflammation alters production and release of glutathione and related thiols in human U373 astroglial cells. Cellular and Molecular Neurobiology. 2013;33(1):19-30. doi: 10.1007/s10571-012-9867-6.
- Daniel Okin D, Medzhitov R. Evolution of Inflammatory Diseases. Current Biology. 2012 Sep; 22(17):R733–R740. doi:10.1016/j.cub.2012.07.029
- Atalay F, Odabasoglu F, Halici M, Cadirci E, Aydin O, Halici Z, et al. N-Acetyl Cysteine Has Both Gastro-Protective and Anti-Inflammatory Effects in Experimental Rat Models: Its Gastro-Protective Effect Is Related to Its In Vivo and In Vitro Antioxidant Properties. Journal of Cellular Biochemistry. 2016;117(2):308-19. doi: 10.1002/jcb.25193.
- Uraz S, Tahan G, Aytekin H, Tahan V. N-acetylcysteine expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic acid-induced colitis in rats. Scandinavian Journal of Clinical and Laboratory Investigation. 2013 Feb;73(1):61-6. doi:10.3109/00365513.2012.734859.
- Yamada M, Tsukimura N, Ikeda T, Sugita Y, Att W, Kojima N, et al. N-acetyl cysteine as an osteogenesis-enhancing molecule for bone regeneration. Biomaterials. 2013;34(26):6147-56. doi: 10.1016/j.biomaterials.2013.04.064.
- Origuchi T, Migita K, Nakashima T, Honda S, Yamasaki S, Hida A, et al. Regulation of cyclooxygenase-2 expression in human osteoblastic cells by N-acetylcysteine. Journal of Laboratory and Clinical Medicine. 2000;136(5):390-4.
- Hou Y, Wang L, Yi D, Wu G. N-acetylcysteine and intestinal health: a focus on its mechanism of action. Frontiers in Bioscience (Landmark Ed). 2015 Jan 1;20:872-91.
- Mancini A, Di Segni C, Raimondo S, Olivieri G, Silvestrini A, Meucci E, et al. Thyroid Hormones, Oxidative Stress, and Inflammation. Mediators of Inflammation. 2016;2016:6757154. doi: 10.1155/2016/6757154.
- Zaletel K, Gaberšček S. Hashimoto’s Thyroiditis: From Genes to the Disease. Current Genomics. 2011;12(8):576-88. doi: 10.2174/138920211798120763.
- Rousset B, Dupuy C, Miot F, Dumont J. Chapter 2 Thyroid Hormone Synthesis And Secretion. Endotext. South Dartmouth, MA: MDText.com, Inc; 2015. https://www.ncbi.nlm.nih.gov/books/NBK285550/. Accessed May 8, 2018.
- Dinicola S, De Grazia S, Carlomagno G, Pintucci JP. N-acetylcysteine as powerful molecule to destroy bacterial biofilms. A systematic review. Eur Rev Med Pharmacol Sci. 2014 Oct;18(19):2942-8.
- Shen F-C, Weng S-W, Tsao C-F, Lin H-Y, Chang C-S, Lin C-Y, et al. Early intervention of N-acetylcysteine better improves insulin resistance in diet-induced obesity mice. Free Radical Research. 2018. DOI: 10.1080/10715762.2018.1447670
- Ma Y, Gao M, Liu D. N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders. Pharm Res. 2016;33(8):2033-2042. doi:10.1007/s11095-016-1941-1.
- Natural Medicines Therapeutic Research Collaboration. https://naturalmedicines.therapeuticresearch.com/. Accessed August 5, 2020.
- Amin AF, Shaaban OM, Bediawy MA. N-acetyl cysteine for treatment of recurrent unexplained pregnancy loss. Reprod Biomed Online. 2008;17(5):722-726. doi:10.1016/s1472-6483(10)60322-7
- Appelboam AV, Dargan PI, Knighton J. Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients with asthma. Emergency Medicine Journal. 2002;19:594-595.