What is myo-inositol?
Myo-inositol is a form of inositol, a type of natural sugar alcohol that’s present in mammalian cells. It is an important nutrient that serves key functions relating to hormone signal transduction throughout our endocrine system. As such, myo-inositol plays an important regulatory role relating to thyroid health.*
What are the benefits of myo-inositol?
Research has shown that myo-inositol supplementation supports optimal thyroid antibody and TSH levels, as well as alleviates mood symptoms associated with anxiety, mood swings, depression and obsessive compulsive disorder (1). Research has also found that myo-inositol relieves menstrual irregularities, acne, insulin resistance, and weight gain associated with PCOS (2).*
What is the recommended dose?
One scoop per day, in six to eight ounces of water or another beverage, is recommended.
When should I take it?
It is recommended to take myo-inositol in the evening before bed, as it can promote restful sleep. I love stirring it into a cup of tea for a hint of sweetness!
Please note: for most people, myo-inositol can be helpful for sleep, due to the blood sugar balancing effect at night. However, some people may react differently. If you experience sleeplessness, discontinue taking it and speak with your practitioner.
How long can I take Myo-Inositol Powder for?
Myo-Inositol Powder can be taken for 6 months or long term, if needed.
Why isn’t it recommended for those with kidney, blood sugar, or bleeding issues?
Myo-inositol may not be properly cleared when the kidneys are overworked, such as in kidney disease, or if taking supplements (such as cleavers) or medications (such as diuretics) that can affect the kidneys or the lymphatic system.
People with diabetes taking myo-inositol should watch for signs of low blood sugar (hypoglycemia), as myo-inositol may lower blood sugar and hemoglobin A1c levels. Rarely, myo-inositol has been associated with nausea, headaches, dizziness, or fatigue.
Some people have reported increased bleeding with the use of myo-inositol, so it is not recommended for those with a history of heavy bleeding, or for those taking blood thinners.
Can it be taken with thyroid medications?
Yes, myo-inositol is safe to take with thyroid medications, but be sure to space them out by at least one hour. Due to its key role in TSH signaling, myo-inositol supplementation has been shown to reduce thyroid antibodies, reduce TSH levels, and even achieve remission in people with Hashimoto’s (3). For this reason, testing your thyroid hormone levels every 30-90 days to see if a medication adjustment is needed, is recommended.*
Not to be used by those who have kidney disease or who may be already taking supplements, such as cleavers (a diuretic herb), that can affect the kidneys or the lymphatic system. Do not use if you are allergic or sensitive to any of the ingredients in this supplement.
DO NOT TAKE if taking the following medications: antidiabetic drugs, or blood thinners.
Consult with a doctor before using if pregnant or breastfeeding, or if you have a history of heavy bleeding. People with diabetes taking myo-inositol, should watch for signs of low blood sugar (hypoglycemia), as myo-inositol may lower blood sugar and hemoglobin A1c levels.
Rarely, myo-inositol has been associated with nausea, headaches, dizziness, fatigue or sleeplessness. If you experience these effects, discontinue taking it.
While research has shown that myo-inositol seems to have a normalizing effect on testosterone in women with PCOS, myo-inositol has been shown to increase testosterone in men with low levels of this hormone. Thus, myo-inositol can be used by both men and women. However, a word of caution for men who are sexually active: myo-inositol can increase sperm quality, leading to surprise pregnancies in partners of men who were previously thought to be infertile.
Please note: Myo-Inositol Powder contains ingredients derived from non-GMO corn, but does not contain a protein component which could cause an antigenic response. While it is generally well-tolerated by those with corn sensitivities, please consult with your practitioner before use if you have individual concerns.
- Unfer V, Facchinetti F, Orrù B, Giordani B, Nestler J. Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials. Endocrine Connections. 2017;6(8):647-658. doi:10.1530/EC-17-0243.
- Formuso C, Stracquadanio M, Ciotta L. Myo-inositol vs. D-chiro inositol in PCOS treatment. Minerva Ginecol. 2015 Aug;67(4):321-5.
- Nordio M, Basciani S. Treatment with Myo-Inositol and Selenium Ensures Euthyroidism in Patients with Autoimmune Thyroiditis. International Journal of Endocrinology. 2017;2017:2549491. doi:10.1155/2017/2549491.
- Natural Medicines Therapeutic Research Collaboration. https://naturalmedicines.therapeuticresearch.com/. Accessed August 5, 2020.